Crystaluria can be avoided provided the CLINICAL PHARMACOLOGY REVIEW Application Number IND 106,153 PIND NDA 18,603 Generic Name Acyclovir Dosage Form and Strength Powder for IV administration (50 mg/mL after Acyclovir is an agent used to treat infections caused by the herpes simplex virus (HSV)
Acyclovir monophosphate is phosphorylated to diphosphate and triphosphate forms by cellular enzymes in the infected host cell where the drug is concentrated
Acyclovir triphosphate inactivates viral deoxyribonucleic acid polymerase
Acyclovir is a synthetic purine analogue (acyclic nucleoside analogue)
PMID: DOI: 10
Introduction Acyclovir (ACV) and valacyclovir (VCV) are antiviral agents used for treatment and prophylaxis of infections with herpes simplex virus (HSV) and varicella zoster virus (VZV) [ 1, 2 ]
Acyclovir is used to treat infections caused by herpes viruses, such as genital herpes, cold sores, shingles, and chicken pox
Preclinical investigation brought the drug to clinical Acyclovir half-life (T1/2 beta) and total body clearance (Cltot) are influenced significantly by renal function, and dosage adjustments should be made for patients with impaired renal function; therefore dosage adjustments based on Clcr will compensate for age-related changes in renal function
The average time to peak concentrations is approximately 2 Acyclovir is an antiviral agent only after it is phosphorylated in infected cells by a viral-induced thymidine kinase
In common with these earlier antivirals, acyclovir is active against some members of the herpesvirus group of DNA viruses
Extensive investigations of the pharmacokinetics in man have shown it to have a useful half-life of about three hours and to be largely excreted unchanged in the urine
On this episode "Acyclovir Pharmacology" I discuss the mechanism of action, important monitoring parameters, and drug interactions with acyclovir
• Acyclovir is a selective antiherpes agent
Mechanism of Action: Acyclovir causes termination of the DNA chain during the viral replication process
The mechanism of Aciclovir (ACV), also known as acyclovir, is an antiviral medication
Acyclovir is an antiviral medication that is used to treat herpes simplex v Acyclovir sodium is a white, crystalline powder with the molecular formula C 8 H 10 N 5 NaO 3 and a molecular weight of 247
Acyclovir is in a class of antiviral medications called synthetic nucleoside analogues
Pharmacokinetic profile of acyclovir in a child receiving continuous kidney replacement therapy for acute liver failure
After intracellular uptake, it is converted to acyclovir monophosphate by virally-encoded thymidine kinase
Acyclovir is an antiviral agent which is highly active in vitro against Herpes simplex (HSV) types I and II and Varicella zoster viruses, but its toxicity to mammalian cells is low
The aim of this study is to provide insight into the pharmacodynamics (PD) of (val)acyclovir
The hidden development of this methodology, an increase in acyclovir monophosphate, is catalysed by thymidine kinase caused by cells contaminated by herpes simplex infection 11 , 12 or varicella zoster infection or DRUG NAME
The major route of elimination of acyclovir is via the kidney by glomerular filtration and renal tubular secretion
At physiologic pH, acyclovir sodium exists as the un-ionized form with a molecular weight of 225 and a maximum solubility in water at 37°C of 2
An important toxic effect of acyclovir is its potential to cause obstructive nephropathy
Learn more about the mechanism, dosage, side effects, and interactions of acyclovir from this book chapter on the NCBI Bookshelf
It is functionally related to a guanine
The chemical name of acyclovir is 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-
1365-2710
The drug may be administered topically to the skin, intravenously, orally, or topically to the eye (only topical and intravenous preparations are currently ACYCLOVIR TABLETS, USP400mg and 800mg
The antiviral process has relatively little effect on normal, uninfected cells
5 mg/mL
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Methods: Patients (age, 8
A clinical pharmacology study was performed with ZOVIRAX Cream in adult volunteers to evaluate the percutaneous absorption of acyclovir
Pharmacology of acyclovir Extensive evaluation in microbial and mammalian cell assay systems suggest that acyclovir does not damage individual genes or components thereof, even in enormous doses
Pharmacodynamics
Acyclovir pharmacokinetics is accurately
Acyclovir is an antiviral agent only after it is phosphorylated in infected cells by a viral-induced thymidine kinase
Acyclovir monophosphate is phosphorylated to diphosphate and triphosphate forms by cellular enzymes in the infected host cell where the drug is concentrated
The drug is excreted primarily by the kidney, which may require smaller doses in patients with decreased kidney function
Acyclovir is an antiviral agent only after it is phosphorylated in infected cells by a viral-induced thymidine kinase
Acyclovir is a new antiviral drug that acts as a specific inhibitor of herpesvirus DNA polymerase
Acyclovir is an antiviral medication that is used to treat herpes simplex v Acyclovir is a selective anti-herpes virus agent
1016/s0190-9622 (88)70022-5
Acyclovir • Acyclovir (acycloguanosine) is the prototypic antiherpetic therapeutic agent
It works by stopping the spread of the herpes virus in the body
Other uses include prevention of cytomegalovirus infections following transplant and severe complications of Epstein–Barr virus infection
Acyclovir is an antiviral agent which is highly active in vitro against Herpes simplex (HSV) types I and II and Varicella zoster viruses, but its toxicity to mammalian cells is low
Acyclovir is the drug of choice for children with herpes virus or CMV infections
Each 800 mg tablet of acyclovir contains 800 mg of acyclovir and the inactive ingredients colloidal silicon dioxide, croscarmellose sodium, magnesium stearate and microcrystalline cellulose
Acyclovir for Injection, USP is a sterile lyophilized powder for intravenous administration only
Herbal Medicine CHN RLE
MECHANISM OF ACTION
The antiviral process has relatively little effect on normal, uninfected cells
It shows good in vitro activity against herpes simplex and varicella-zoster viruses
D
Acyclovir (9- [2-hydroxymethyl]guanine) is a nucleoside analog that selectively inhibits the replication of herpes simplex virus types 1 and 2 (HSV-1, HSV-2) and varicella-zoster virus (VZV)
The maximum solubility in water at 25°C exceeds 100 mg/mL
The major route of elimination of acyclovir is via the kidney by glomerular filtration and renal tubular secretion